MXE, also known as methoxetamine, is a substance with similar chemical properties to ketamine and phencyclidine (PCP). These are two illicit drugs known for their hallucinogenic and dissociative properties. T is an odorless, white powder that may be taken orally, inhaled through the nose, or injected.
Methoxetamine users may experience pleasurable feelings of euphoria and enlightenment for up to 24 hours after using the drug 2. However, taking too much or having a bad reaction to MXE may lead to psychiatric, cognitive, neurological, and/or cardiovascular problems.
Despite legal restrictions placed on the recreational use of similar drugs, PCP and ketamine, there are currently no federal restrictions on the sale of MXE in the United States
Physical properties of MXE
The hydrochloride salt of methoxetamine is a white, odorless crystalline powder at room temperature. A physical description of the freebase form could not be found in readily accessible literature.
Pharmacology Of Methoxetamine
In research examining the pharmacological profile, data suggests that methoxetamine has affinity for the N-methyl-D-aspartate (NMDA) receptor and acts as an antagonist. Also, it is similar to the related ketamine but it has a longer duration of action than that of ketamine.. In addition similarly to ketamine, methoxetamine also involves dopamine and serotonin reuptake inhibition. No studies have been performed examining the pharmacology and mode of action of methoxetamine in humans.
Pharmacokinetics of MXE
There are no published formal animal or human studies examining the pharmacokinetic properties of methoxetamine. Users report rapid onset of action (10-20 minutes) following nasal insufflation, rectal or intravenous/intramuscular administration.
The sublingual route is reported as less effective, with oral least effective. Peak effects are reported to occur between 1-3 hours after exposure with a further duration of between three and six hours during which after-effects are experienced.
There are a few reports of effects lasting 24 hours; the half-life for clinical effects is three hours .